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The AMPK-dependent upregulation of PDKs may represent an adaptive metabolic reprogramming strategy to maintain essential metabolic functions within the muscle, emphasizing the metabolic underpinnings of cachexia

Furthermore, it has also been demonstrated that hypoxia-driven CSC enrichment in breast cancer originates from a dedifferentiation process and that hypoxia-inducible factors (HIFs) are essential for chemotherapy resistance in breast CSCs ( 8 Strategies to Overcome Breast Cancer Resistance 8.1 Endogenous Molecule Inhibitors Various endogenous molecules, such as E-cadherin (Kim WD